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Sionna Therapeutics, Inc. is projected to rise to $59.49 by 2027, a +27% move from its current price of $46.78. SION is currently trading above its 50-day average (a bullish sign). Technical indicators currently lean strong buy.
A data-driven summary — not financial advice. See the full breakdown below.
Live market data via Yahoo Finance · updated 7/31/2026
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Aug 1 | $45.27 | $46.81 | $48.40 | +0.06% |
| Aug 2 | $44.67 | $46.84 | $49.10 | +0.12% |
| Aug 3 | $44.23 | $46.86 | $49.66 | +0.18% |
| Aug 4 | $43.86 | $46.89 | $50.13 | +0.24% |
| Aug 5 | $43.54 | $46.92 | $50.56 | +0.30% |
| Aug 6 | $43.25 | $46.95 | $50.95 | +0.36% |
| Aug 7 | $43.00 | $46.97 | $51.32 | +0.42% |
| Period | Min | Prediction | Max | Change |
|---|---|---|---|---|
| Week 1 | $43.00 | $46.97 | $51.32 | +0.42% |
| Week 2 | $41.62 | $47.17 | $53.46 | +0.83% |
| Week 3 | $40.64 | $47.37 | $55.21 | +1.25% |
| Week 4 | $39.85 | $47.56 | $56.77 | +1.68% |
| Week 5 | $39.19 | $47.76 | $58.21 | +2.10% |
| Week 6 | $38.62 | $47.96 | $59.57 | +2.52% |
| Week 7 | $38.11 | $48.16 | $60.86 | +2.95% |
Short-term targets derived from the forecast trend and recent volatility. Highly uncertain — not financial advice.
Sionna Therapeutics, Inc. is a clinical-stage biopharmaceutical company focused on medicines for the treatment of cystic fibrosis (CF). It develops galicaftor (SION-2222), a transmembrane domain 1 (TMD1)-directed CFTR that has completed Phase 2 trial; navocaftor (SION-3067), a potentiator that has completed Phase 2 trial; SION-109, an intracellular loop 4 directed CFTR corrector that has completed Phase 1 trial; SION-2851, a TMD1-directed CFTR corrector that has completed Phase 1 trial; SION-451, which is nucleotide-binding domain 1 stabilizer in Phase 1 trial; and SION-719, which is nucleotide-binding domain 1 stabilizer in Phase 2a proof-of-concept trial.
The company was formerly known as Sling Therapeutics, Inc. and changed its name to Sionna Therapeutics, Inc. in July 2021. Sionna Therapeutics, Inc. was incorporated in 2019 and is headquartered in Waltham, Massachusetts.
Sionna Therapeutics, Inc. (SION) operates in Healthcare. Its current price is $45.69, with a market cap of $2.06B and a rank of 1908. The stock sits in a price environment that the forecast describes as bullish over the longer term.
The 30-day range around the current price spans from $35.92 to $58.12, and the stock shows a bullish technical bias with a 14-day RSI around 60, and key moving averages at $40.96 for the SMA50 and $39.07 for the SMA200.
A major floor 32.4% below — a decisive break under it would weaken the trend.
The nearest floor, 21.5% below — buyers have tended to step in here.
The nearest ceiling, 5.6% above — a clean break opens room to run.
A major ceiling 21.8% above — clearing it would confirm fresh momentum.
Key SION support and resistance from recent price action — levels where the trend has historically paused or reversed. Percentages are the distance from the current price.
A snapshot of SION market posture derived from its technical indicators and recent volatility. Higher trend and alignment lean bullish; higher risk means larger swings.
Technical Analysis
Indicators computed on daily closing prices.
| Period | SMA | Action | EMA | Action |
|---|---|---|---|---|
| MA 5 | $45.84 | Buy | $45.90 | Buy |
| MA 10 | $46.06 | Buy | $45.62 | Buy |
| MA 20 | $45.16 | Buy | $44.74 | Buy |
| MA 50 | $41.47 | Buy | $42.69 | Buy |
| MA 100 | $40.51 | Buy | $41.00 | Buy |
| MA 200 | $39.74 | Buy | $37.86 | Buy |
| Name | Value | Action |
|---|---|---|
| RSI (14) | 56.66 | Neutral |
| Stoch RSI (14) | 30.20 | Neutral |
| CCI (20) | 99.34 | Neutral |
| Williams %R (14) | -38.56 | Info |
| MACD (12,26,9) | -0.13 | Sell |
| ROC (12) | 9.84 | Buy |
| Bollinger %B (20,2) | 0.77 | Neutral |
| Stochastic %K (14) | 61.44 | Neutral |
| TRIX (15) | 0.52 | Buy |
| Awesome (5,34) | 3.10 | Buy |
| Ultimate (7,14,28) | 51.23 | Neutral |
| Momentum (10) | 1.49 | Buy |
| Aroon Osc (25) | 64.00 | Buy |
| Hull MA (9) | 45.93 | Buy |
| ADX (14) | 14.67 | Neutral |
| ATR (14) | 1.54 | Info |
In the near term, the technical picture is bullish. The 30-day range runs from $35.92 up to $58.12, suggesting ample movement within the month. The SMA50 sits at $40.96 and the SMA200 at $39.07, providing nearby support and trend context.
| Year | Min | Avg | Max | ROI | Sentiment |
|---|---|---|---|---|---|
| $33.51 | $46.78 | $64.25 | 0% | Neutral | |
| $46.47 | $59.49 | $81.09 | +27% | Bullish | |
| $49.12 | $65.15 | $92.86 | +39% | Bullish | |
| $56.51 | $77.20 | $113.89 | +65% | Bullish | |
| $63.17 | $88.58 | $134.49 | +89% | Bullish | |
| $79.24 | $113.78 | $177.14 | +143% | Bullish | |
| $97.06 | $142.52 | $226.88 | +205% | Bullish | |
| $105.44 | $158.11 | $256.83 | +238% | Bullish | |
| $111.65 | $170.83 | $282.65 | +265% | Bullish | |
| $109.00 | $170.02 | $286.16 | +263% | Bullish | |
| $190.25 | $324.22 | $585.96 | +593% | Bullish | |
| $394.82 | $787.28 | $1,576.37 | +15.8x | Bullish |
Current year — the forecast is anchored to the live price, so ROI shows 0%.
| Month | Min | Avg | Max | Change |
|---|---|---|---|---|
| July 2026 | $33.51 | $46.78 | $54.63 | +0.00% |
| August 2026 | $40.03 | $47.20 | $57.13 | +0.90% |
| September 2026 | $41.45 | $49.38 | $60.74 | +4.62% |
| October 2026 | $43.03 | $51.69 | $64.40 | +4.67% |
| November 2026 | $42.33 | $51.20 | $64.46 | -0.94% |
| December 2026 | $41.55 | $50.57 | $64.25 | -1.25% |
Click any year to see its month-by-month SION forecast. Min / Avg / Max are a bear / base / bull scenario; ROI is the projected move from the current price. Change is the month-over-month move in the average. Estimates, not guarantees.
The SION price prediction for 2026 points to an average of $46.78 (low $33.51, high $64.25) — a potential gain of 0% on today's $46.78. Price action looks broadly range-bound.
In 2027, SION is projected to trade between $46.47 and $81.09, averaging $59.49 — a potential gain of +27% from today's $46.78. That is up +27% on the projected 2026 average. Buyers look set to stay in control over this stretch.
Sionna Therapeutics, Inc.'s 2028 outlook centres on $65.15, within a $49.12 to $92.86 range. That is up +10% on the projected 2027 average. That marks a +39% change versus current levels. Momentum favours further upside here.
By 2029, SION could reach as high as $113.89, with a base case around $77.20 and support toward $56.51 — roughly +65% from $46.78. Buyers look set to stay in control over this stretch.
Expect SION to range from $63.17 to $134.49 through 2030. The $88.58 average target implies a +89% move from current prices. That is up +15% on the projected 2029 average. Momentum favours further upside here.
The SION price prediction for 2031 points to an average of $113.78 (low $79.24, high $177.14) — a potential gain of +143% on today's $46.78. Buyers look set to stay in control over this stretch.
In 2032, SION is projected to trade between $97.06 and $226.88, averaging $142.52 — a potential gain of +205% from today's $46.78. That is up +25% on the projected 2031 average. Momentum favours further upside here.
Sionna Therapeutics, Inc.'s 2033 outlook centres on $158.11, within a $105.44 to $256.83 range. That is up +11% on the projected 2032 average. That marks a +238% change versus current levels. Buyers look set to stay in control over this stretch.
By 2034, SION could reach as high as $282.65, with a base case around $170.83 and support toward $111.65 — roughly +265% from $46.78. Momentum favours further upside here.
Expect SION to range from $109.00 to $286.16 through 2035. The $170.02 average target implies a +263% move from current prices. That is 0% versus the projected 2034 average. Buyers look set to stay in control over this stretch.
The SION price prediction for 2040 points to an average of $324.22 (low $190.25, high $585.96) — a potential gain of +593% on today's $46.78. Momentum favours further upside here.
In 2050, SION is projected to trade between $394.82 and $1,576.37, averaging $787.28 — a potential gain of +15.8x from today's $46.78. That is up +143% on the projected 2040 average. Buyers look set to stay in control over this stretch.
Investing $1,000 in SION today (≈ 21.376657 SION) could be worth
$16,829.49
+$15,829.49 (+1583%) by 2050 · US Dollar
Based on the average projected SION price of $787.28 in 2050.
Based on the base (average) forecast scenario. FX rates are indicative. Estimates only — not financial advice.
See what a past investment in SIONwould be worth at today's price.
$1,000 invested in SION on Jul 30, 2025 (≈ 56.338028 SION) would be worth
$2,635.49
+$1,635.49 (+163.5%) today · 2.64× · US Dollar
Based on a SION entry price of $17.75 vs. today's $46.78.
| Invested | Entry price | Value today | Return |
|---|---|---|---|
| 1 week ago | $44.06 | $1,061.73 | +6.2% |
| 1 month ago | $43.99 | $1,063.42 | +6.3% |
| 3 months ago | $39.15 | $1,194.89 | +19.5% |
| 6 months ago | $42.26 | $1,106.96 | +10.7% |
| 1 year ago | $17.75 | $2,635.49 | +163.5% |
| All time (1.5y) ago | $25 | $1,871.2 | +87.1% |
Past performance from historical market data — it does not predict future results. FX rates are indicative. Not financial advice.
Enter a price to see how it sits against our SION forecast.
Our base-case forecast reaches $94.00 around 2031.
Implied market cap at $94.00: $4.24B
The year-by-year forecast shows a rising trajectory from 2026 through 2050. The 2026 average price is $45.69 with a min of $33.51 and a max of $63.51. By 2027 the average is $57.39 with a max of $79.56 and a 25.6% ROI, and by 2028 the average is $60.28 with a max of $87.67 and a 31.9% ROI.
The forecast climbs to a 2030 average of $80.50 (max $125.31) with a 76.2% ROI, and extends to 2040 with an average of $274.45 (max $514.55) and a 500.7% ROI, then to 2050 with an average of $660.29 (max $1,379.92) and a 1,345.2% ROI. Throughout these years, sentiment remains bullish, reflecting an expectation of substantial upside.
Tap a question to reveal the answer.
In 2030, the forecasted average price is $80.50 with a max of $125.31 and a min of $56.07; the ROI is 76.2% and the sentiment is BULLISH.
The forecast shows bullish sentiment in multiple years (e.g., 2027-2050) with rising average prices from $57.39 in 2027 to $660.29 in 2050, and notable ROIs such as 25.6% in 2027, 31.9% in 2028, 57.2% in 2029, 76.2% in 2030, 500.7% in 2040, and 1,345.2% in 2050.
Yes. The 2030 max price in the forecast is $125.31.
The 30-day range is from $35.92 to $58.12.
The current price is $45.69 and the market cap is $2.06B, with a rank of 1908.
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